FLU NEWS FROM ICAAC: H1N1 studies, IV peramivir findings, Tamiflu for H5N1

first_imgSep 14, 2009 (CIDRAP News) – A wide range of research findings on pandemic H1N1 influenza, seasonal flu, and avian flu was presented over the weekend at the 49th annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in San Francisco (www.icaac.org).Triple antiviral therapy better than single drugsA triple combination therapy comprising three flu antiviral drugs—amantadine, oseltamivir (Tamiflu), and ribavirin—controls replication of flu viruses better than any of those drugs used independently, according to a multi-national team. Researchers from Adamas Pharmaceuticals in California, Utah State University, the Naval Health Research Center of San Diego, the University of Alabama, and Amsterdam Medical Center in the Netherlands tested the drugs alone and in combination in vitro against H1N1 flu viruses and also against seasonal flu strains that were resistant to amantadine and oseltamivir. (Nguyen JT, et al: “In vitro activity of triple combination therapy against drug-resistant influenza viruses.”)Rapid flu tests miss H1N1 casesRapid tests may not detect novel H1N1 flu as well as slower, more expensive molecular tests do, raising the possibility of under-counting and missed diagnoses, according to researchers from the University of South Florida College of Medicine and Tampa General Hospital. The team took tested samples from suspected flu patients using a rapid test and a polymerase chain reaction (PCR) test, and compared both results with a second test by the Florida Department of Health. Sixty-six patients tested positive for influenza A at the Department of Health, but the in-hospital PCR detected only 48 of them and the rapid test only 18. The rapid test also returned 18 false-positives. (Montero JA, et al: “Discordance between a rapid antigen test and PCR for detection of influenza in the current setting of an evolving pandemic of novel H1N1.”)Link between immunoglobulin levels and H1N1 severity seenThe results of a study from three institutions in Melbourne, Australia, suggest that administering immunoglobulin to patients with severe H1N1 infection may mitigate the impact of the disease, particularly in pregnant women who appear to be more vulnerable. The group assessed levels of total serum immunoglobulin as well as particular immunoglobulin subclasses in patients with moderate H1N1 infection and in those with severe cases requiring intensive care, some of whom were pregnant, as well as in uninfected pregnant women. They found that pregnant women infected with H1N1 were more likely to have lower levels of immunoglobulin, and that levels were lower in severe cases than in mild ones. (Gordon CL: “Association between severe swine-origin influenza A virus [S-OIV] infection and immunoglobulin G2 subclass deficiency.”)MRSA as fatal complication in H1N1 casesBacterial co-infections should be considered a dangerous complication of H1N1 infection, researchers from the Women’s and Children’s Hospital of Buffalo, N.Y., and two other institutions warned. The group described severe infections in a 9-year-old girl and a 15-year-old boy who arrived at the emergency room several days after being seen for mild flu symptoms. Both children died of necrotizing pneumonia caused by infection with methicillin-resistant Staphylococcus aureus (MRSA) as a secondary complication of H1N1 flu. (Johnson KK, et al: “Two fatal pediatric cases of pandemic H1N1/09 influenza complicated by community-acquired methicillin-resistant Staphylococcus aureus [CA-MRSA]”)IV peramivir compares well with Tamiflu for seasonal fluA single intravenous (IV) dose of the experimental antiviral drug peramivir worked as well as a course of oral oseltamivir (Tamiflu) in a study in Asia, according to an Associated Press (AP) report from the ICAAC meeting. Flu patients were given either a single IV dose of peramivir (300 or 600 mg) or 5 days of oseltamivir, the AP reported. Symptoms cleared in 78 or 81 hours with the lower and higher doses of peramivir, respectively, and in 82 hours with oseltamivir, the story said. Dr. Shigeru Kohno of Nagasaki University, the lead researcher, said side effects were less common with peramivir. But flu expert Dr. Fred Hayden noted that many patients last winter had oseltamivir-resistant strains of flu.Oseltamivir improves survival in H5N1 and seasonal fluRoche, maker of Tamiflu, reported two retrospective studies indicating that the drug significantly improved survival rates in H5N1 avian flu and seasonal flu patients. In the analysis of avian flu cases, 11 of 89 patients (12%) who did not receive the drug survived, versus 45 of 85 (53%) of those who received at least one dose up to 8 days after falling ill. The study is described as the first to systematically assess human H5N1 cases in multiple countries. The other study was an analysis of 760 patients in Hong Kong who had severe seasonal flu, half of whom received oseltamivir. The mortality rates were 6.0% in the untreated group compared with 3.8% in the treated group, a 37% reduction, according to Roche.[Sep 13 Roche press release]H1N1 described as all-ages infectionCompared with seasonal flu, H1N1 flu causes more infections in teenagers and adults and is also responsible for more intensive care unit (ICU) admissions, according to an analysis by the Toronto Invasive Bacterial Diseases Network. A comparison of the clinical features and outcomes of 154 seasonal flu infections in the 2007-08 flu season, along with the first 158 H1N1 infections in the Toronto region, showed that H1N1 infections were more evenly distributed across age-groups and were more likely to occur in children and adults with underlying conditions. (Rebbapragada A, et al: “A comparison of clinical features and outcomes of hospitalization due to seasonal and pandemic influenza A [H1N1].”)Severe H1N1 cases in childrenAlthough H1N1 infection is often mild, 16% of 80 children admitted to a Montreal children’s hospital in May and June required ICU care, 13% were experiencing seizures or other neurologic symptoms at admission, and 35% had abnormally low oxygen levels on arrival. One child died. Two-thirds of the children had underlying conditions—asthma, sickle-cell disease, encephalopathy, and others— that may have predisposed them to illness, said researchers at the Ste. Justine Hospital Research Centre. (Laumay E, et al: “Novel influenza A [H1N1] related hospitalization in a pediatric tertiary care centre: who’s at risk for severe disease?”)News editor Robert Roos contributed to this report.last_img read more

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A new space of the Museum of Modern and Contemporary Art in Rijeka has been opened

first_imgThe H-building of the former Benčić factory is the first building in that complex, in which one of the city’s cultural institutions has moved in – the Museum of Modern and Contemporary Art. This also began the process of transforming Benčić into Rijeka’s cultural district.It is a facility that was originally built for the needs of the factory plant of a tobacco factory in the 90s of the 19th century. The part that was added between the wings of the building, along Krešimirova Street, was created in the 30s. The original purpose of the building was industrial. In the first phase of renovation, which was completed in July, according to the project of architect Dinko Peračić, the space was minimalistically arranged to meet the requirements for regular activities of the Museum. The value of the performed works amounted to HRK 20, and the arrangement was financed from the Budget of the City of Rijeka.As the architect Peračić explained, the Museum will be further developed in phases, in such a way that any further intervention in the unarranged part of the building will become part of the new whole. All necessary security and technical systems have been created that enable the modern use and development of museum activities. The first phase of the renovation put part of the ground floor and the first floor into operation. The works that have been done are primarily related to the arrangement of the interior space for the functioning of the gallery activity. The total area of ​​the arranged space is 1550 mXNUMX.The full functionality of the museum with all the necessary facilities is planned to be realized in the second stage in which the expansion of the Museum to the rest of the space on the ground floor and the two upper floors is expected. One of the values ​​of the exhibition space is the retention of the floors and the original shape, with minimal repairs, which together with the load-bearing pillars, gives the space a modern note and patina at the same time. The entrance hall in the southern part of the ground floor is also a living room, a place to stay with an info desk that should function as a space for smaller events, but primarily as an orientation space that directs visitors to exhibitions and educational content. Upstairs is an exhibition space that has direct access to the stairs, separately for staff and visitors.Let us remind you that in the first half of 2020, the city of Rijeka will be the heart and bloodstream of Croatian culture European Capital of Culturelast_img read more

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Valamar Riviera awarded for best investor relations

first_imgAt the 27th conference of the Zagreb Stock Exchange and the 11th conference of the fund industry held in Rovinj, Valamar Riviera once again received the award for the best investor relations, which has been awarded by Poslovni dnevnik and the Zagreb Stock Exchange for eight years.This award recognizes companies for the high level of communication quality and transparency in relation to investors, and in the competition for the best investor relations this year were companies from the CROBEX index and companies listed on the Official Market of the Zagreb Stock Exchange. The order of the winners was decided according to statistical criteria related to compliance with the Rules of the Zagreb Stock Exchange and on the basis of a survey conducted among capital market participants.”High transparency and the quality of business and financial communication are the foundation of our relationship with investors. In this way, we continuously promote Valamar Riviera as one of the leading shares on the Croatian capital market and tourist shares in this part of the region. We are extremely honored to be recognized as the best among the investor and financial community and I am sure that with their support we will continue to create added value for all our stakeholders.”Said Marko Čižmek, a member of the Management Board of Valamar RivieraOn that occasion, the President of the Management Board of the Zagreb Stock Exchange, Ivana Gažić, stated: “When we launched this award in collaboration with Poslovni dnevnik in 2010, we were driven by the desire to continuously identify and reward good practices in our market. We are extremely pleased to congratulate Valamar Riviera because this award is a strong encouragement and example to others and sends the message that excellence is recognized and ultimately rewarded.”last_img read more

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Graffiti on Gradele in the race for the title of best summer festival

first_imgWho says graffiti doesn’t go along with grills?Nearly 2 and a half thousand visitors circulated daily through the White House, and during the three days of the event they were able to enjoy top-notch music and street art for free. For the seventh time in a row, this deadly combination ignited Bol on Brač in the middle of the tourist season and became a central gathering place for young graffiti artists, street art artists, designers, musicians, DJs, skaters and hungry visitors.In the period from 26 to 28 July, Brač became the most urban Croatian island promoting street art. This is supported by the interest of many domestic, regional and world names in the graffiti scene to leave their mark on the walls of the White House. So this year, Zoer and Velvet from France and Flying Fortress from Germany visited Croatia, names that are at the very top of world street art. Visitors witnessed the eternal conflict of realism and utopia of Zoe’s works, which tries to fit its part of reality into the space in which he draws. Velvet draws its inspiration from the everyday environment, and its hyper-realistic approach to content often goes back to the beginnings in which marine and industrial themes occupied an important place in his poetics, and there is the legendary Flying Fortress, a model for many generations in his 30-year career. Also, the team was joined by Spaniards Sebas Velasco and Inigo Sesma and local and regional forces Lunar, Chez 186, Sarme, Arte, Wuper, Nikola Mihajlovic, Casino, Royal, Smack, Mosk and Senk.The musical line-up was certainly attractive to the guests. The program offered the best of Croatian hip-hop: Krankšvester, Vojko V, Stoka, High5, Kuku $, Buntai and Tone Tuoro and DJ forces: Oliver, Tikach, VRH, Rofellos, Zembo, Kuna, Babilonska, Resk, Gang Gang, Ineskich , Niki Peducci and Traples.Fascinating is the fact that the extremely rich program is free of charge for the seventh year in a row, which is in the spirit of urban festivals, but still emphasizes the role that visitors have with the organizers. Especially if we add to that the fact that this is the very peak of the tourist season. In addition, the festival in cooperation with Flixbus provided visitors with a discount on bus rides to Split and a discount on accommodation in partner camps and cheaper apartment rental prices in the agency Adria Bol and Bol Homes. A good example of how the whole community actually lives through the festival, but also proof that a successful festival must be something more than content – it must be a complete arrangement that creates a feeling of closeness in the visitor and increases the likelihood of his return.This year’s Graffiti started in China Mediteran Bol, and as part of the opening, visitors were able to watch video projections from last year’s editions. The heart of the Festival is the abandoned White House Hotel near the Dominican convent and the beach. Visitors were able to show their talents in drawing on “Ziggi best papers design” and drawing postcards for the campaign “Carefree greetings from the Adriatic”, and those eager to dance could participate in numerous “battles” or in the dancehall session Cromaicanza, but still of art: at the Jagermeister table football tournament, the diving competition, the lufting race and the daily street basketball tournament.Nearly 2 and a half thousand visitors circulated daily through the White House, proving that this simple formula practiced by the organizers is the secret to the success of an urban festival that has recently sprung up from all sides as opposed to their large and commercial versions. Yet, even in that endless offer of street festivals, those who rightly carry that attribute stand out. The whole community can and should be included in it, which literally means the denominator urban. If it doesn’t engage a society that makes it urban and ultimately a product of life in it, then it’s simply a festival and a bunch of free content with no sensitive story.It is commendable to see that this is being worked on in Croatia as well.last_img read more

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27 facilities in Zagreb County received the Cyclist Welcome Quality quality standard

first_imgAfter the adoption of the Operational Plan for the Development of Cyclotourism in Zagreb County until 2020, the Zagreb County Tourist Board decided to identify and additionally market facilities that offer catering, information and other tourist services intended for cyclists, and organize and network them into an integrated tourist product.With the aim of positioning Zagreb County as a cycling tourist destination of high quality service, and based on insights into examples of good practice of European cycling tourist destinations, quality standards have been developed in cooperation with RAM DC doo Cyclist Welcome Quality, stand out from the Zagreb County Tourist Board.Thus, in the area of ​​Zagreb County, conducted by evaluation, 27 facilities met the conditions for entry into Cyclist Welcome network, and they were handed plates with the official visual identity and categorization marks with a gift set of basic equipment for bicycle service.List of buildings in Zagreb County – Cyclist Welcome Qualitylast_img read more

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Reconstruction of the mining tower in Labin begins

first_imgThe procurement announced by the City of Labin is estimated at 1,9 million kuna plus VAT and the deadline for submission of bids is February 11, 2019, and the start of work is planned immediately after the conclusion of the Public Procurement Contract. As part of the project, the basic load-bearing structure of Šoht will be replaced, all metal treads and the existing gallery around the tower will be replaced. Corrosion protection of the entire tower will also be implemented. The MINE TOUR project, carried out by the City of Labin, deals with the challenge of the untapped tourist potential of the mining heritage, namely the natural monument of the Sitarjevec mine in Litija and the Labin Šoht. The partners are the Municipality of Litija, the Development Center of the Heart of Slovenia, the Civil Engineering Institute of Slovenia, the Tourist Board of the Istrian County, Labin Art Express XXI and the Tourist Association of Slovenia. The deadline for the execution of works is 31 December 2019. Technical specifications for each type of work are listed in the cost estimate and in the main project prepared by the company STUDIO ARHING doo Zagreb. By the way, this is a MINE TOUR project in which the City of Labin was approved 2,5 million kuna in grants for the renovation of the manhole. The goal of the project is to actively preserve the mining heritage and connect it into a unique tourist product. In the electronic public procurement notice of the Republic of Croatia, a tender notice was published for the execution of works on steel structures of the static rehabilitation of the mining tower – Šohta.last_img read more

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Karlovac County and Karlovac are richer by 15 interpretation guides

first_imgIt is in this segment that Karlovac County sees its opportunity for growth and development. Thus, with the aim of raising the quality of heritage interpretation services and guide services, the Karlovac County Tourist Board and the Karlovac Tourist Board organized the training of professionals who meet the need for heritage interpretation in their work, which should be adapted to different target groups.  “This education is a continuation of the activities we carry out in the city of Karlovac together with all partners. Our goal is to respond to new trends and raise the value and quality of the destination. Since the education is focused on a different, more interesting presentation of natural and cultural heritage, we are sure that it will help everyone who participated to present Karlovac in a quality way, and to achieve a common goal, and that is a satisfied guest.” said Marina Burić, director of the Tourist Board of the city of Karlovac. The training program includes a 40-hour training, is licensed by the Interpret Europe association, and the educator is the first licensed interpretation guide in Croatia and the author of the Secret Zagreb tour, Mrs. Iva Silla. Interpret Europe is a European professional association that brings together about 1000 professionals in the field of heritage interpretation from 55 countries. “Nowadays, most tourists and visitors truly enjoy getting to know new locations, their history and culture, and this is one of the most common travel motives when choosing a destination. But these historical curiosities are more impressive if they are presented in a way that evokes emotion and encourages interaction between the guide and the group, and this education program is just going in that direction. In this context, we can say that with this intensive five-day program we want to adapt to today’s trends and at the same time give this opportunity to all those who want to improve their knowledge and interpretation skills. The ultimate goal of all these activities is to raise the quality of services in the destination, and the interest of participants showed that we are on the right track”Said Dina Begić, director of the Karlovac County Tourist Board. Photo: TZ Karlovac And there is no better way than telling stories than through storytelling, whose main mantra is – sell me a story, not a product. A group of 15 registered participants in Karlovac started the course in mid-November. The theoretical part was held in the area of ​​Aquatika and the Franciscan monastery, while the practical part was held at various locations in the city and county. The wish of the organizers and participants of the course is that the richness of heritage is worthily passed on to visitors through interesting facts, facts, information, emotions and experience. I keep emphasizing how tourism consists of emotions, experiences and stories. It is our authentic stories that are the strongest content that makes us unique and that, after all, creates the motive of coming, because people travel to meet and experience a new way and culture of living. People travel to experience something new and different. Tell stories. Our authentic stories.last_img read more

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Vouchers for saving Croatian tourism as a light at the end of the tunnel?

first_imgWhat is certain is that this season they can “save”, ie provide at least some inflow of money, only domestic guests, and weekend trips will also be relevant. In addition to Vouchers, Pointers will promote the entire drip on social networks and publish more than 200 videos and VR360 content from Croatia, placement of promotional videos of destinations and reports “Piece of Croatian Paradise” through local TV stations that have already joined this action and communication with tourism agencies in the surrounding countries by sending smart catalogs of Croatian destinations. The statistics of our online channels show us that in these times of crisis in the world, regardless of the situation, the interest in viewing video and virtual reality content that represents Croatia is growing every day, Weinpert points out and adds: “Concrete figures give us hope and show that tourists, both domestic and foreign, have not given up on beautiful destinations in Croatia and that we must not give up on promoting the tourism sector at this timeWeinpert points out. Find out how to join this commendable initiative and how you can buy vouchers HERE Although it is not yet known or anyone has a solution as to what these vouchers should possibly look like on the field and how they should be realized, the DMC agency Pointers Travel from Osijek, which launched a positive campaign, stands out as a light at the end of the tunnel. TRUST AND FRIENDSHIP for the recovery of Croatian tourism, with which they want to intensify marketing activities mostly in the domestic market, and when the measures related to COVID-19 start to weaken, also in the foreign market. Goal Voucher’s TRUST AND FRIENDSHIP is initiating the flow of money to the economic sector in tourism, initiating the flow of money to the economic sector in tourism, ensuring the inflow of fresh money by advance payments – by purchasing Vouchers by customers, all to help the tourism sector overcome the coronavirus crisis. So everything is free and there is no profit. This is at least for now the first concrete proactive and positive move with the goal of what to do the day after the coronavirus. The least we can do is send beautiful pictures from Croatia, let our guests, both domestic and foreign, dream and plan, as well as to support their previous hosts in our tourism. It’s up to the people. Let’s support and get involved in this initiative, because this is one of the possible solutions that gives us the opportunity to see at least some light at the end of the tunnel and to try to save what to save yes from this year. And for that we all need to activate, not wait. A light at the end of the tunnel? Namely, vouchers can be used in the next minimum of one year from the date of purchase, and when using the voucher, the customer achieves a minimum of 25% higher value. They see their optimism from Pointers in the growing interest in video and VR360 content on their online channels. center_img We actively involve the entire tourism sector in the campaign, our companions, tourists, guests and all partners, locally and globally, he points out. Krunoslav Weinpert from Pointers and adds: “All marketing activities, posting and promotion of information online are done by Pointers without any financial compensation, as a thank you to our partners for their trust and to contribute to the situation in our business sector.. We invite you to give your contribution to this action by supporting the Croatian tourism sector by joining this action, promoting it, sharing this information, inviting the tourism sector to contact us to place their vouchers online” Although the whole story looks great and the whole initiative with vouchers is more than commendable, at first glance it may seem that the team from Pointers may have taken too big a bite, ie you set too big a goal. But when we look at the whole picture, it is a complete and rounded project, not just a form, and that is why this initiative should definitely be supported. Also, the credibility of Pointers is certainly a guarantee that this is not an empty PR story, but a serious project. “The goal is to sell as many vouchers as possible in advance to secure cash flow in the tourism sector. Also, we have distributed all our destination videos to local TV stations that have already started broadcasting them, in order to at least start a tourist activity in Croatia, because the focus will certainly be on the domestic guest. ” concludes Weinpert. Also, there is a campaign “Vacation week worth” as well as a Cro card from the Ministry of Tourism, projects that should have been active, and can be activated as soon as the day after the coronavirus. Currently, the tourism sector is quietly talking about vouchers for the tourism sector, as one of the solutions to save this tourist season, ie to at least somehow activate the tourist activity of the local population to get at least some cash flow and save what can be saved. Vouchers enable customers in Croatia and around the world to help caterers, hoteliers, private renters and other participants in tourism with their purchase now, when it is most needed. And the peculiarity of the whole campaign is the introduction Vouchers to help the entire tourist sector. Side dish: See how it works in more detail in the presentationlast_img read more

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Survey for private renters on the impact of the Corona virus on business

first_imgYou can fill out the survey until 14.07.2020. You can access the survey via the link https://www.hgk.hr/forms/anketni-upitnik-poslovanje-obiteljskog-smjestaja-u-vrijeme-koronavirusa  The Family Tourism Association of the Croatian Chamber of Commerce has published a survey for private renters on the impact of the Corona virus on their business.center_img The survey aims to gain insight into how the current situation regarding the Corona virus (COVID-19) affects the non-business of catering service providers in the household and on the family farm.last_img read more

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Alplaus development will be harmful to town

first_imgCategories: Letters to the Editor, Opinion As a resident of Alplaus since 1977, I am firmly against the proposed Prime Mohawk development of 228 units. This development would more than double the population of Alplaus. It in no way would be beneficial or compatible with the surrounding land uses.Alplaus is a lovely, quiet, walking hamlet, where we enjoy a neighborly lifestyle. Besides doubling our population, this development would greatly increase traffic and destroy a beautiful section of the Mohawk River shoreline that is zoned land conservation.Maybe that doesn’t mean anything to the developer, or even to the Glenville Town Board, but it’s why many of us set down roots here. The addition of this monstrous development makes no sense.The town supervisor has repeatedly told us that the reason for this high-density project is to offset the cleaning of a brownfield where the Mohawk Industrial Park now sits. I firmly believe that it is the present owner’s responsibility to clean this site. The contamination there is well documented, and he has known about it for years. Passing the buck to a builder and then having Alplaus residents deal with the aftermath is shameful.We welcome responsible development with forethought and mindfulness to preserve our hamlet’s integrity as well as its natural surroundings.Kathleen BoyleAlplausMore from The Daily Gazette:Schenectady County warns of possible COVID-19 exposure at Schenectady restaurant, Rotterdam barLocal movie theater operators react to green lightFoss: Should main downtown branch of the Schenectady County Public Library reopen?EDITORIAL: Urgent: Today is the last day to complete the censusEDITORIAL: Thruway tax unfair to working motoristslast_img read more

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